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S. Thomas Carmichael, MD, PhD

[CONTACT INFORMATION]
UCLA Department of Neurology
710 Westwood Plaza
Los Angeles, CA 90095
Phone: (310) 206-0550
E-mail: scarmichael@mednet.ucla.edu

[AFFILIATION]
UCLA Department of Neurology
Associate Professor

[EDUCATION & CERTIFICATION]
MD, Washington University School of Medicine, 1986-1994
PhD, Washington University School of Medicine, 1988-1993
Medicine Internship, Barnes Hospital/Washington University School of Medicine, 1994-1995
Neurology Residency, Washington University School of Medicine, 1995-1998
Board Certification, Neurology, 2000 (re-certification pending)
Neurorehabilitation Fellowship, UCLA School of Medicine, 1998-2001

[AWARDS & RECOGNITION]
American Society of Neurorehabilitation Outstanding Clinician-Scientist Award , 2009
Larry L. Hillblom Foundation Distinguished Scholar Award, 2005
Frontiers in Science, UCLA Faculty Development Award, 2003
Howard Hughes Medical Institute Physician Post-Doctoral Research Fellow, 1998-2001

[RESEARCH INTERESTS]
Neural repair and recovery after stroke

[RESEARCH INTEREST TOPIC AREAS]
Aging
Neural repair
Regeneration
Stroke

[SELECT PUBLICATIONS]
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&ter...

[PRINCIPAL INVESTIGATOR NIH GRANTS]

NEURAL REPAIR AFTER STROKE

MECHANISMS OF NEURONAL REGENERATION AFTER STROKE IN A NOVEL NEUROVASCULAR NICHE

MECHANISMS OF NEURAL REPAIR IN WHITE MATTER STROKE

MECHANISMS OF NEURAL REPAIR IN WHITE MATTER STROKE

STROKE STEM CELL/HYDROGEL THERAPY

[OTHER GRANTS]
Title - Embryonic-Derived Neural Stem Cells for Treatment of Motor Sequelae followig Sub-Cortical Stroke
Funding Source - California Institute of Regenerative Medicine
Grant Number - DRl-Ol480
PI Name - Gary Steinberg
Key Words for Search Engine - stroke, stem cells, neural repair
Duration of Grant - 4 years

Abstract or lay summary:
The goal of the research described in this proposal is to bring a human stem cell derived product, SD56, to IND filing for treatment of motor sequelae of sub-cortical stroke. SD56 is a neural precursor cell line that is amendable to large-scale production sufficient for an appropriate quality assurance program that is required for multi-center clinical trials. SD56 engraftment into the peri-infarct area of a rodent stroke model has been shown to improve neurologic outcome. In order to develop assays for the potency of SD56, we have evaluated the mechanisms involved in the SD56-mediated improvement of recovery from stroke. Our research has identified endogenous repair mechanisms enhanced by SD56 transplantation by secretion of trophic factors. To increase the survival of transplanted cells, as well as their ability to produce/deliver trophic factors, we are injecting the cells in a hydrogel matrix, which may lead to greatly increased efficacy. We have designed a research program that encompasses the development and manufacture of the SD56 line, the pharmacology and toxicology of SD56 transplanted with and without hydrogel all within a framework of operation that will meet regulatory requirements for IND filing.

For non-NIH grant/project #1, please select all applicable topic areas:
stroke, stem cells

Non-NIH Grant/Project #2
Title - Larry L Hillblom Network for Neural Repair after Stroke
Funding Source - Larry L Hillblom Foundation
PI Name - S. Thomas Carmichael
Key Words for Search Engine - stroke, brain mapping, neural repair
Duration of Grant - 5 years
This grant combines four investigators into a study of cellular and molecular events that underlie plasticity in cortical brain maps, neuronal dendritic reorganization and recovery in mice and humans after stroke.

For non-NIH grant/project #2, please select all applicable topic areas:
stroke, brain mapping, neural repair